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The DETERMINATOR

Generalist Deep Research Agent - Stops at Nothing Until Finding Precise Answers

The DETERMINATOR is a powerful generalist deep research agent system that uses iterative search-and-judge loops to comprehensively investigate any research question. It stops at nothing until finding precise answers, only stopping at configured limits (budget, time, iterations).

Key Features: - Generalist: Handles queries from any domain (medical, technical, business, scientific, etc.) - Automatic Source Selection: Automatically determines if medical knowledge sources (PubMed, ClinicalTrials.gov) are needed - Multi-Source Search: Web search, PubMed, ClinicalTrials.gov, Europe PMC, RAG - Iterative Refinement: Continues searching and refining until precise answers are found - Evidence Synthesis: Comprehensive reports with proper citations

Important: The DETERMINATOR is a research tool that synthesizes evidence. It cannot provide medical advice or answer medical questions directly.

Features

  • Generalist Research: Handles any research question from any domain
  • Automatic Medical Detection: Automatically determines if medical knowledge sources are needed
  • Multi-Source Search: Web search, PubMed, ClinicalTrials.gov, Europe PMC (includes bioRxiv/medRxiv), RAG
  • Iterative Until Precise: Stops at nothing until finding precise answers (only stops at configured limits)
  • MCP Integration: Use our tools from Claude Desktop or any MCP client
  • HuggingFace OAuth: Sign in with your HuggingFace account to automatically use your API token
  • Modal Sandbox: Secure execution of AI-generated statistical code
  • LlamaIndex RAG: Semantic search and evidence synthesis
  • HuggingFace Inference: Free tier support with automatic fallback
  • Strongly Typed Composable Graphs: Graph-based orchestration with Pydantic AI
  • Specialized Research Teams of Agents: Multi-agent coordination for complex research tasks

Quick Start

# Install uv if you haven't already (recommended: standalone installer)
# Unix/macOS/Linux:
curl -LsSf https://astral.sh/uv/install.sh | sh

# Windows (PowerShell):
powershell -ExecutionPolicy ByPass -c "irm https://astral.sh/uv/install.ps1 | iex"

# Alternative: pipx install uv
# Or: pip install uv

# Sync dependencies
uv sync

# Start the Gradio app
uv run gradio run src/app.py

Open your browser to http://localhost:7860.

For detailed installation and setup instructions, see the Getting Started Guide.

Architecture

The DETERMINATOR uses a Vertical Slice Architecture:

  1. Search Slice: Retrieving evidence from multiple sources (web, PubMed, ClinicalTrials.gov, Europe PMC, RAG) based on query analysis
  2. Judge Slice: Evaluating evidence quality using LLMs
  3. Orchestrator Slice: Managing the research loop and UI

The system supports three main research patterns:

  • Iterative Research: Single research loop with search-judge-synthesize cycles
  • Deep Research: Multi-section parallel research with planning and synthesis
  • Research Team: Multi-agent coordination using Magentic framework

Learn more about the Architecture.

Documentation